Epidermis的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列問答集和整理懶人包

Differential Diagnoses in Surgical Pathology: Non-Neoplastic Dermatopathology

為了解決Epidermis的問題，作者Cook, Deborah L. 這樣論述：

Offering expert, practical guidance through the decision-making process, Differential Diagnoses in Surgical Pathology: Non-Neoplastic Dermatopathology, by Dr. Deborah L. Cook, helps you systematically solve tough diagnostic challenges in skin pathology and arrive at a correct diagnosis between co

mmonly confused entities. In this all-new title, lesions are presented side by side for easy comparison, with clinical and pathological findings in short outline format followed by several full-color images. In addition to illustrating and discussing the classical features of these entities, the aut

hor emphasizes atypical features that can complicate diagnoses. Provides side-by-side comparisons for each major differential diagnosis, helping you distinguish between commonly confused non-neoplastic dermatopathology lesions Contains more than 850 full-color photographs that depict the features of

each entity and cover major differential diagnoses in this challenging area Covers inflammatory disorders and alterations of the epidermis and dermis, blistering diseases, disorders of the adnexae and subcutis, infectious diseases, and more Ideal for practicing pathologists, pathologists in trainin

g, residents, and medical students Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Epidermis進入發燒排行的影片

Matriptase在口腔癌細胞惡性化及藥物治療中扮演角色之研究

為了解決Epidermis的問題，作者廖恆毅 這樣論述：

據衛生福利部統計，自民國81年以來，惡性腫瘤已成為台灣第一大死因，口腔癌死亡率在全台灣排名為第六位，並在台灣男性中位列第四位。流行病學調查顯示，大約近九成的口腔癌患者有嚼食檳榔的習慣。檳榔中的主要成分檳榔鹼，它是誘發腫瘤發生和腫瘤進展的主要致癌物質。口腔癌治療目前主要方法為外科手術切除後，或聯合放射治療和化學治療。然而，這些治療方法受多種因素的影響，特別在腫瘤較大或合併轉移的病患上並不完全有效。因此，目前迫切需要進一步了解口腔癌相關機制，以提高治療的效果。Matriptase是膜結合絲氨酸蛋白酶，它與不同類型表皮起源的癌症進展有關，包括口腔粘膜和鱗狀上皮。過去的研究表明，matriptase

的過度表達會導致人類細胞的癌症進展和預後不良。因此本研究將探討matriptase 在口腔癌惡性化及抗藥性中所扮演的角色。本研究使用檳榔鹼反覆刺激培養的人類口腔癌細胞 (OEC-M1)，產生更惡性化的口腔癌細胞。為了評估口腔癌細胞受檳榔致癌物影響的變化，研究應用全自動細胞紀錄系統 (ECIS) 來記錄細胞微運動、增殖、遷移和侵襲。matriptase與惡性化及抗藥性的相關途徑，則透過西方點墨法進行分析比較。另外，使用臨床一線的化療藥物順鉑 (Cisplatin)，以及過去研究中能明顯抑制腫瘤細胞生長的穿心蓮內酯 (Andrographolide)及大麻二酚 (Cannabidiol)，探討m

atriptase在癌症治療中對抗藥性的影響。為了確認matriptase扮演的角色，本研究使用CRISPR/Cas9技術剔除OEC-M1中的matriptase，並與控制組做對照。結果顯示，在口腔癌惡性化實驗中，在經過多次的高濃度檳榔鹼篩選後，OEC-M1的遷移能力跟抗藥性皆有增加，並且matriptase 的表現量有增加的趨勢，在matriptase基因剔除後，口腔癌細胞的增生及遷移能力有明顯的降低。在抗藥性的實驗中，matriptase剔除後，不同藥物對OEC-M1的毒性明顯增加，造成更多的細胞凋亡。在本研究中，matriptase 在癌細胞惡性化和相關化學藥物治療中扮演重要的角色。相信

在未來相關應用的研究可提升癌症化學藥物治療的效果，並降低預後不良的發生。

3D Bioprinting: Modeling in Vitro Tissues and Organs Using Tissue-Specific Bioinks

為了解決Epidermis的問題，作者Cho, Dong-Woo,Kim, Byoung Soo,Jang, Jinah 這樣論述：

Prof. Dong-Woo Cho received his Ph.D. in Mechanical Engineering from the University of Wisconsin-Madison in 1986. Ever since, he has been a professor in the Department of Mechanical Engineering at the Pohang University of Science and Technology. He is the director of the Center for Rapid Prototyping

-based 3D Tissue/Organ Printing. His research interests include 3D microfabrication based on 3D printing technology, and its application to tissue engineering and more generally to bio-related fabrication. He has recently focused his attention on tissue/organ printing technology and development of h

igh-performance bioinks. He serves or has served on the editorial boards of 11 international journals. He has published over 280 academic papers in various international journals in manufacturing and tissue engineering and has contributed chapters to ten books as well as writing a textbook related t

o tissue engineering and organ printing. He has received many prestigious awards including ＂the mystery of life＂ award at The Roman Catholic Archdiocese of Seoul (2018, January) and ＂the respect life＂ award from LINA Foundation 50+ awards (2019, April). He was also awarded the Nam-Go chair professor

ship at POSTECH.Prof. Jinah Jang received her Ph.D. at the Division of Integrative Biosciences and Biotechnology at POSTECH in 2015, and she worked as postdoctoral fellow in the Department of Mechanical Engineering at POSTECH (2015-2016) and the Institute for Stem Cell and Regenerative Medicine/Depa

rtment of Pathology and Bioengineering at the University of Washington (2016-2017). She joined POSTECH in the spring of 2017 as an assistant professor in creative IT engineering. Her research focuses on the building the functional human tissues from stem cells via 3D bioprinting technology and print

able biomaterials, particularly based on tissue-specific bioinks. Her successful achievements may lead to clinical applications for providing advanced therapeutic methods, understanding disease mechanisms, and engineering micro-tissue models.Dr. Byoung Soo Kim received his Ph.D. in Mechanical Engine

ering from POSTECH in 2019. During an MS and PhD integrated program at the Department of Mechanical Engineering in POSTECH under the guidance of Prof. Dong-Woo Cho, his research focused on 3D printing system development, dECM-based bioink formulation, and in vitro tissue biofabrication. He is partic

ularly focused on 3D cell printing of in vitro human skin models. He has suggested a novel platform for matured 3D skin constructs by employing a printable functional transwell system, rather than using commercial transwell inserts. Furthermore, he formulated a porcine-skin-derived tissue-specific b

ioink and applied it to skin tissue engineering. A vascularized and perfusable human skin equivalent composed of an epidermis, dermis, and hypodermis was 3D cell-printed and matured. Based on his previous achievements, he is now working on in vitro skin disease modeling for better pathophysiological

studies.Dr. Ge Gao received his master’s degree from Huazhong University of Science and Technology (HUST) and his Bachelor’s degree from Harbin Institute of Technology (HIT), majoring in Materials Science. Since 2014, he has been a Ph.D. student at the Department of Mechanical Engineering at POSTEC

H. His current research focuses on 3D cell-printing of vascular constructs and their applications as in vitro vascular platforms and in vivo blood vessel bypass grafts. In addition, he also developed a vascular-tissue-specific bioink that can facilitate the functionalization of the fabricated vascul

ar equivalents. These achievements might be useful for a wide range of biomedical applications, from modeling blood vessel relevant diseases to building vascularized tissues/organs.Mr. Wonil Han received his bachelor’s degree in Life Science from Handong Global University in 2015. Since then, he has

been a graduate student on an MS and Ph.D. integrated program, at the Department of Integrative Bioscience and Biotechnology at POSTECH under the supervision of Prof. Dong-Woo Cho. His research interests include liver tissue engineering and regenerative medicine via 3D cell printing technology, the

regulatory effect of dECM bioinks of normal tissues on the fibrotic disease models, and big data analysis of differential stem cell behaviors in dECM bioinks from different kinds of tissues.Dr. Narendra K. Singh has completed his Ph.D. in Materials Science from the Indian Institute of Technology-Ba

naras Hindu University (IIT-BHU), India in 2012 and has subsequently joined as a postdoctoral research fellow in the Department of Polymer Science and Engineering, Sungkyunkwan University, South Korea (2013-2015). He is currently a postdoctoral research fellow under prof. Dong-Woo Cho at the Departm

ent of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), South Korea. His research interests include biomaterials, proteomics analysis of dECM bioinks, 3D cell-printing technology, and regenerative medicine. In particular, his current research focuses on the 3D cell-prin

ting of microfluidic kidney-on-a-chip for the development of in vitro disease models and drug toxicology advancement. He has published 12 research articles in internationally reputed peer-reviewed journals and two book chapters. His research work has been selected for the cover page of Nanosci. Nano

technol. Lett, 1: 52-56 (2009), and his work (J. Mat. Chem. 21:15919-15927 (2011) has been highlighted in Nature India.

探討matriptase及其下游的HGF/c-Met訊息傳遞路徑對胃癌進程的影響

為了解決Epidermis的問題，作者鄭若涵 這樣論述：

胃癌（gastric cancer, GC）為全球十大癌症之一，其中90%以上為腺癌（adenocarcinoma）。當胃黏膜發炎未治療復原，可能會演變成癌前病變，包括胃部腸化生（intestinal metaplasia, IM）以及異常增生（dysplasia），進而走向癌症的發生。目前胃癌的預後仍然不佳，而癌細胞的生長、侵襲和轉移則是預後的關鍵，許多蛋白水解酶（protease）會在過程中扮演重要的角色。本研究要探討的matriptase為絲胺酸蛋白水解酶，在先前的文獻中指出，在許多癌症中，包括乳癌、大腸癌、前列腺癌、甲狀腺癌等，matriptase的表達以及活化態會增加，而matri

ptase活化後會促進細胞外基質的水解，並且活化肝細胞生長因子（hepatocyte growth factor, HGF）及其接受器c-Met，進而促進癌症的進程；然而matriptase的活性會被抑制蛋白HAI-1所調控，但目前這些蛋白在胃癌中的表現以及調控機制還不是很清楚。因此本研究使用免疫組織染色（immunohistochemistry, IHC）來觀察matriptase、HAI-1以及c-Met在胃癌以及癌前病變中的表現，以及與胃癌細胞株AGS的生長、遷移、侵襲和凋亡的相關性，並且在細胞中加入PI3K抑制劑LY294002、EGFR抑制劑PD153035以及MEK抑制劑PD980

59，來對相關訊號傳遞路徑做進一步的探討。我們的結果發現：（1）與正常的胃黏膜組織相比，total matriptase、活化態matriptase以及c-Met在胃癌組織中表現會增加，而HAI-1在兩者間沒有顯著差異。（2）在胃部腸化生組織中發現，total matriptase、活化態matriptase、HAI-1以及c-met的表達均會增加。（3）活化態matriptase的表現會隨著胃癌進程而逐漸增加；相反的，HAI-1的表現會在癌前病變時顯著增加，並且隨著進程逐漸下降。（4）使用Kaplan-Meier plotter分析胃癌患者生存率發現，在分化不良的胃癌患者中，matripta

se高表達會有較差的生存率。（5）使用CRISPR將胃癌細胞株AGS的matriptase進行knockout後，發現並不會影響細胞的生長，但是會顯著抑制細胞的遷移和侵襲，並且細胞凋亡會增加，從免疫螢光染色的結果也可以看到，ki67的表現在基因剔除後沒有顯著差異，而MMP-9的表現在基因剔除後有明顯的下降。（6）挑選了幾個路徑的抑制劑對AGS細胞處理，結果發現在加入LY294002之後，matriptase的活化會顯著地受到抑制，因此我們認為matriptase的活化與PI3K路徑有關。