First secondary的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列問答集和整理懶人包

Social Studies for the Twenty-First Century: Methods and Materials for Teaching in Middle and Secondary Schools

為了解決First secondary的問題，作者Zevin, Jack 這樣論述：

Jack Zevin is Emeritus Professor of Social Studies Education at Queens College, City University of New York, USA.

First secondary進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決First secondary的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Social Studies for the Twenty-First Century: Methods and Materials for Teaching in Middle and Secondary Schools

為了解決First secondary的問題，作者Zevin, Jack 這樣論述：

Jack Zevin is Emeritus Professor of Social Studies Education at Queens College, City University of New York, USA.

新媒體宣傳對品牌形象提升之個案研究

為了解決First secondary的問題，作者樊仲諭 這樣論述：

隨著網際網路及資通訊技術的進步，為傳播帶來了近乎全新的變革。傳播平台和傳播途徑得以以更多元的形式及載具接收，打破了傳統媒體的限制。同時，整合行銷傳播模式的運用，使得傳播者與閱聽者之間的關係，產生了前所未有的變化。有別於傳統媒體，新媒體開創了獨特的受眾組成和訊息傳播模式，更進一步提升了準確性、使用者體驗及互動性。在這多變的情況下，企業或品牌必須重新構建一種符合新媒體特性的品牌傳播策略，以便於更貼近閱聽者的心理需求，促使閱聽者化被動為主動分享及傳播品牌訊息。本研究有鑑於上述狀況，以本土品牌「A品牌電腦」的新媒體傳播策略為個研究對象，採用個案研究法、次級資料分析法及針對相關媒體平台之操作數據進行分

析，研究該品牌在新媒體發展蓬勃的現今時代，如何以整合式行銷手法操作跨界行銷之宣傳行為，最後歸納出「A品牌電腦」在社群優化改善建議，作為日後品牌新媒體經營策略之參考。