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父母社會經濟地位對於兒童出生健康與學齡前階段發展協調障礙之間關聯性之調節效應

為了解決Td FN165的問題，作者TRAN HUYNH TRUC 這樣論述：

Background and Purpose: Developmental Coordination Disorder (DCD) is characterized by motor difficulties in daily activities. These problems may occur during the early developmental period; however, they could not be explained by intellectual delay, visual impairment, or other neurological conditio

ns. Socioeconomic status (SES) and birth health have been found to predict DCD, respectively. However, there is a lack of research taking into account the effects of SES and birth health simultaneously and examining the potential moderating effect of parental SES on the relationship between birth he

alth and DCD during early childhood. Therefore, the objectives of this study were to (1) compare the differences in parental SES and birth health between children with and without DCD, and (2) to investigate whether parental SES would moderate the effect of birth health on DCD in preschool children.

Methods: One hundred and twenty-two children aged between 4 and 6 years participated in this study. The Movement Assessment Battery for Children – 2nd Edition (MABC-2) test was used to assess children’s motor coordination. After excluding children with physical disabilities or intelligent impairmen

t, children were categorized into either the DCD group (16th %ile, n=99) based on the result of the MABC-2 test. Data on parental SES (i.e., parental education level, parental job status, and the annual household income) and birth health (i.e., birth weight, birth length, head circumstance, gestatio

nal age, and Apgar score at 5 minutes) were obtained from parents using a self-report questionnaire. Mann-Whitney U test and Chi-square test were used to examine the differences in parental SES and birth health between the TD and DCD groups. Furthermore, moderation analysis was conducted using the P

ROCESS macro for SPSS, and 95% confidence intervals with a bootstrap procedure were calculated to identify the significant moderating effect. Results: There were no significant differences in parental SES and birth health between the TD and DCD groups. However, when the moderation models were examin

ed, maternal education was found to moderate the relationship between birth length and the probability of having DCD (Effect = 0.7217, bootstrap SE = 0.3337, 95% CI = 0.0677, 1.3758). A significant moderating effect was also found for maternal job on the relationship between birth length and the pro

bability of having DCD (Effect = 0.7184, bootstrap SE = 0.2993, 95% CI = 0.1317, 1.3050). In addition, the relationship between birth weight and the probability of having DCD was moderated by the annual household income (Effect = -0.0004, bootstrap SE = 0.0002, 95% CI = -0.0008, -0.000). Conclusions

: Our findings suggested that the lower level of maternal education and maternal unemployment would strengthen the negative relationship between birth length and the probability of having DCD. Additionally, the negative relationship between birth weight and the probability of having DCD is statistic

ally significant in families with high annual household salaries. Clinical Relevance: This study helps identify and raise awareness of families who may be at greater risk of having a child with DCD. Our findings would also provide important academic implications for further studies to investigate th

e buffering mechanisms in this matter.

以分子與細胞的角度建立探討腎形紋葉珊瑚有性生殖機制的工具和技術

為了解決Td FN165的問題，作者邱顗陵 這樣論述：

數十年來，石珊瑚的有性生殖引起了許多研究者和大眾的注意，在珊瑚生態學的研究中已有許多珊瑚有性生殖的資料，但珊瑚有性生殖的內在機制仍然不清楚，只有少數的研究指出珊瑚配子生成過程和產卵相關的基因和激素/類激素物質。本研究為以分子與細胞的角度建立探討珊瑚有性生殖機制的工具和技術。以腎形紋葉珊瑚Fimbriaphyllia ancora為實驗物種，建立F. ancora生殖腺轉錄體資料庫，當作研究珊瑚配子生成過程中分子和細胞機制的基礎，瞭解性別和階段特異性基因的表現情況和找到與卵母細胞發育/成熟、精子發生和精子運動/獲能相關的基因(第2章)。接著建立F. ancora生殖腺細胞分離及分散F. anc

ora的精巢組織的技術，利用內生性的綠色螢光蛋白(GFP)作為精巢體細胞的標記蛋白，分離出精巢體細胞和生殖細胞(第3章)。為了未來的功能性試驗，建立F. ancora建立卵巢的體外培養系統，篩選出適當的培養條件並培養卵巢，其可以在體外存活且維持卵巢結構6天(第4章)。這些工具和技術都是在珊瑚研究中首次被建立的，這些數據、工具及技術提供了研究珊瑚有性生殖內在機制的基礎。